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About 60% of the time blood comes from the right marginal artery and 40% of the time from the left marginal artery weight loss pills energy cheap xenical 60 mg online. Blood usually comes from the posterior interventricular artery regardless of whether that has originated from the right or left coronary artery 348 weight loss pills uk cheap xenical online visa. The major venous return system of the heart extreme weight loss discount 60 mg xenical with mastercard, the coronary sinus weight loss pills prescription xenical 60 mg amex, empties into which of the following structures Inferior vena cava Left atrium Right atrium Right ventricle Superior vena cava 349. A 36-year-old male bartender is brought by ambulance to your emergency room because a patron jumped over the bar, grabbed an ice pick, and stabbed him in the chest rather than pay his bar tab at the end of the night. The ice pick entered the chest about 2 cm to the left of the sternum in between the fourth and fifth rib. Upon examining the bartender, you note very little blood is coming from the puncture wound and normal lung sounds from both the right and left lung. However, his heart is beating rapidly at 100 beats per minute, his external jugular veins are bulging, and you have difficulty hearing his heart sounds. Hemothorax Pneumothorax Cardiac tamponade Aortic valve stenosis Deep venous thrombosis 468 Anatomy, Histology, and Cell Biology 350. He is brought to the emergency room because he can no longer walk due to weakness, and he is feeling faint. All his heart sounds are distant and muffled and his blood pressure is low despite a very rapid pulse. Insert it just under the left tip of the xiphoid process in an effort to remove blood from the pericardial cavity b. Insert it at the second intercostal space on the left side of the sternum in an effort to inject nitroglycerine in an effort to increase the strength of cardiac contractions. Insert it at the ninth intercostal space at the left midclavicular line in an effort to remove blood from the pleural cavity d. Insert it at the fourth intercostal space on the right side in an effort to remove blood from the right pulmonary artery. Insert it just under the left clavicle in an effort to remove blood from the right cephalic vein Thorax 469 351. Your patient reports he spent two weeks on a desert island as part of a television survival show. Right upper lobe Right middle lobe Right lower lobe Left upper lobe Left lower lobe 470 Anatomy, Histology, and Cell Biology 352. A 36-year-old male office worker comes to the clinic complaining of general weakness and shortness of breath. Cardiac auscultation reveals a diastolic rumbling murmur attributable to the mitral valve. Left side adjacent to the sternum in the second intercostal space Left side adjacent to the sternum in the fifth intercostal space Left side in the midclavicular line in the fifth intercostal space Right side adjacent to the sternum in the second intercostal space Right side adjacent to the sternum in the fourth intercostal space 353. While listening to her lungs, which do sound congested, you also listen to her heart. While three of the valves sound normal the valve sound at the second intercostal space just to the right of the sternum sounds stenotic. In addition to mild pneumonia, which one of the following other conditions should be further evaluated for potential treatment Pneumothorax Ventricular septal defect Aortic valve stenosis Pulmonary valve stenosis Mitral valve prolapse 354. The girl has just joined a recreational soccer team for the first time and she is not as fast as most of the girls her age and both of her legs hurt all over during and after soccer practices. The nurse checked her blood pressure upon arrival and was shocked at how high it was, 150/90. Upon physical exam, you reconfirm the hypertension in both arms and feel a weak femoral pulse just below her inguinal ligament.

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Although the finger-like extensions of the gallbladder resemble villi weight loss pills 751 buy cheapest xenical, they represent changes that occur in the mucosa with increasing age weight loss jump start buy generic xenical on line. The bile is synthesized by hepatocytes and transported from the liver to the gallbladder weight loss 08873 best 60mg xenical. Intraepithelial lymphocytes (labeled with the asterisks) are lymphocytes that have crossed the basal lamina weight loss 8 week program cheap xenical 120 mg online. The intraepithelial lymphocytes may respond to antigen in the lumen of the small bowel. Enterocytes are the absorptive cells of the gut and possess numerous microvilli on their apical surfaces. Paneth cells and enteroendocrine cells contain granules, but secrete lysozyme [regulation of flora (answer e)] and endocrine peptides (answer d), respectively. Hemolytic jaundice is associated predominantly with unconjugated hyperbilirubinemia. The overproduction of bilirubin occurs because of accelerated intravascular erythrocyte destruction or resorption of a large hematoma. When hepatic uptake and excretion of urobilinogen are impaired or the production of bilirubin is greatly increased. In contrast, cholestasis [arrested flow of bile due to obstruction of the bile ducts (intrahepatic)] or extrahepatic biliary obstruction interferes with the intestinal phase of bilirubin metabolism and leads to significantly decreased production and urinary excretion of urobilinogen. Diapedesis of lymphocytes across the endothelium of the postcapillary high endothelial venules of lymphoid organs. The direction of flow is from the hepatocytes toward the bile duct, which drains bile from the liver on its path to the gallbladder, where the bile is stored and concentrated. The hepatic artery and hepatic portal vein (shown in the photomicrograph) plus the bile duct comprise the portal triad. Blood flows from the triad (hepatic artery, portal vein, and bile duct) toward the central vein, whereas bile flows in the opposite direction toward the triad. The neonatal small intestinal epithelium also has an increased capacity for absorption of unconjugated bilirubin, which contributes to the elevated serum levels. Bilirubin, a product of iron-free heme, is liberated during the destruction of old erythrocytes by the mononuclear macrophages of the spleen and, to a lesser extent, of the liver and bone marrow. The hepatic portal system brings splenic bilirubin to the liver, where it is made soluble for excretion by conjugation with glucuronic acid. Increased plasma levels of bilirubin (hyperbilirubinemia) result from increased bilirubin turnover, impaired uptake of bilirubin, or decreased conjugation of bilirubin. In Crigler-Najjar syndrome, a defect in glucuronyl transferase occurs in the neonate. Gastrointestinal Tract and Glands Answers 337 the ability of mature hepatocytes to take up and conjugate bilirubin may be exceeded by abnormal increases in erythrocyte destruction (hemolytic jaundice) or by hepatocellular damage (functional jaundice), such as in hepatitis. Finally, obstruction of the duct system between the liver and duodenum (usually of the common bile duct in the adult and rarely from aplasia of the duct system in infants) results in a backup of bilirubin (obstructive jaundice, see question 218 and feedback). The presence of pain (in the right upper quadrant radiating to the shoulder) after eating a meal consisting of fried foods makes gallstones the most probable diagnosis. Similar pain often occurs in these patients when they have not eaten for long periods of time and then have a large meal. The pain is caused by the obstruction of the cystic duct or common bile duct that produces increased lumenal pressure within the bile vessels, which cannot be compensated for by cholecytokinin-induced contractions. The result is defective dentin, discoloration of the translucent teeth (blue-gray or yellow-brown color). Those teeth are weaker than normal, making them prone to rapid decay, wear, breakage, and loss. Type I occurs in conjunction with 338 Anatomy, Histology, and Cell Biology osteogenesis imperfecta with mutations in type I collagen; children with type I have typical blue sclerae with defects in bone and dentin. The structure labeled B is dentin, which consists of mineralized collagen synthesized by odontoblasts. The pulp of a mature tooth (labeled D in the diagram) consists primarily of loose connective tissue rich in vessels and nerves. Odontoblasts lie at the edge of the pulp cavity and secrete collagen and other molecules, which mineralize to become dentin (B). Mineralization of the matrix occurs around the odontoblast processes and forms dentinal tubules. Ameloblasts, which are ectodermal derivatives, lay down an organic matrix and secrete enamel, initially onto the surface of the dentin.

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Longterm penicillin prophylaxis weight loss pills with green tea cheap xenical 60mg with amex, preferably with intramuscular benzathine penicillin G weight loss zone diet order xenical with amex, 1 weight loss tips for men cheap 60 mg xenical free shipping. The prognosis of acute rheumatic fever depends on the degree of permanent cardiac damage weight loss pills 30lbs in 30 days xenical 60mg on line. Asymmetrical septal hypertrophy and left ventricular outflow tract obstruction are seen in hypertrophic cardiomyopathies. Endomyocardial biopsy specimens, obtained while the patient is hemodynamically stable, identify histologic type and allow tests for mitochondrial or infiltrative diseases. It is most often viral in origin, with many viruses identified as causative agents. A bacterial etiology is rare but causes a much more serious and symptomatic pericarditis. Staphylococcus aureus and Streptococcus pneumoniae are the most likely bacterial causes. Pericarditis is associated with collagen vascular diseases, such as rheumatoid arthritis, and is seen with uremia (Table 148-1). Postpericar diotomy syndrome is a relatively common form of pericarditis that follows heart surgery. Supportive therapy, including diuretics, inotropic medica tions, and afterload reduction, is provided for all three types of cardiomyopathy. Because of the high mortality rate associated with all forms of cardiomyopathy, cardiac transplantation must be considered. Common (viral pericarditis or myopericarditis is probably the most common cause of acute pericarditis in a previously normal host). The faster the fluid accumulates, the sooner the patient is hemodynamically compromised and develops symptoms. There is no specific treatment for viral pericarditis other than antiinflammatory medications. In many blood disorders, a detailed pedigree identifying a pattern of inheritance can point to the diagnosis. Diagnosis of pediatric blood disorders requires a detailed knowledge of normal hematologic values and varies according to age and, after puberty, according to sex (Table 149-2). Directed by the history, physical examination, and screening laboratory studies, specific diagnostic testing can confirm the diagnosis. Acute episodes of anemia may be life-threatening, presenting with impairment of perfusion and cognitive status. The presence of petechiae, purpura, or deeper sites of bleeding, including generalized hemorrhage, indicates abnormalities of platelets, coagulation factors, or both. Severe types of anemia, thrombocytopenia, and pancytopenia often are associated with congenital anomalies and a pattern of growth delay. Organ system involvement (especially hepatosplenomegaly and lymphadenopathy) or systemic illness point to a generalized illness as the cause for hematologic abnormalities (Table 149-1). An extremely premature infant may have significant extramedullary hematopoiesis due to limited bone marrow hematopoiesis. During infancy, virtually all marrow cavities are actively hematopoietic and the proportion of hematopoietic to stromal elements is quite high. As the child grows, hematopoiesis moves to the central bones of the body (vertebrae, sternum, ribs, and pelvis), and the marrow is gradually replaced with fat. Hemolysis or marrow damage may lead to marrow repopulation of cavities where hematopoiesis previously had ceased or may delay the shift of hematopoiesis. Hepatosplenomegaly in patients with chronic hemolysis may signify extramedullary hematopoiesis. When a patient with cytopenia is being evaluated, a bone marrow examination provides valuable information about processes that lead to underproduction of circulating cells. In addition, bone marrow infiltration by neoplastic elements or storage cells often occurs in concert with infiltration in the spleen, liver, and lymph nodes. Small compartment of pluripotential progenitor stem cells that resemble small lymphocytes and are capable of forming all myeloid elements 2. Large compartment of committed, proliferating cells of myeloid, erythroid, and megakaryocytic lineage 3.

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