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A differential response to pressure acne you first purchase betnovate cheap online, so that heavier pressure produced more tooth movement than lighter pressure acne vulgaris pictures buy betnovate 20 gm on line, would make it possible to move some teeth more than others skin care while pregnant cheap betnovate express, even though some undesired tooth movement occurred acne extractions cheap 20 gm betnovate overnight delivery. In fact, the threshold for tooth movement appears to be quite low, but there is a differential response to pressure, and so this strategy of "divide and conquer" is reasonably effective. Tooth movement increases as pressure increases up to a point, remains at about the same level over a broad range, and then may actually decline with extremely heavy pressure. The best definition of the optimum force for orthodontic purposes is the lightest force that produces a maximum or near-maximum response. When that point is reached, the amount of tooth movement becomes more or less independent of the magnitude of the pressure, so that a broad plateau of orthodontically effective pressure is created. Forces greater than that, though equally effective in producing tooth movement, would be unnecessarily traumatic and, as we will see, unnecessarily stressful to anchorage. Anchorage Situations From this background, we can now define several anchorage situations. A simple example is what would occur if two maxillary central incisors separated by a diastema were connected by an active spring (Figure 8-20). A somewhat similar situation would arise if a spring were placed across a first premolar extraction site, pitting the central incisor, lateral incisor, and canine in the anterior arch segment against the second premolar and first molar posteriorly. Whether this would really produce reciprocal tooth movement requires some thought. Certainly the same force would be felt by the three anterior teeth and the two posterior teeth, since the action of the spring on one segment has an equal and opposite reaction on the other. The larger the root, the greater the area over which a force can be distributed, and vice versa. Therefore, with a simple spring connecting the segments, the anterior teeth would move slightly more than the posterior teeth. As this diagram shows, the first molar and second premolar in each arch are approximately equal in surface area to the canine and two incisors. This reduces the pressure on the anchor units, moving them down the slope of the pressure­response curve. As Figure 8-22 illustrates, too much force destroys the effectiveness of reinforced anchorage by pulling the anchor teeth up onto the flatter portion of the pressure­response curve. Then the clinician is said to have slipped, burned, or blown the anchorage by moving the anchor teeth too much. Stationary Anchorage the term stationary anchorage, traditionally used though inherently less descriptive than the term reinforced anchorage, refers to the advantage that can be obtained by pitting bodily movement of one group of teeth against tipping of another (Figure 8-23). In the first case (A1M1), the pressure for the teeth to be moved is optimal, whereas the pressure in the anchor unit is suboptimal, and the anchor teeth move less (anchorage is preserved). In the second case (A2-M2), although the pressure for the anchor teeth is less than for the teeth to be moved, both are on the plateau of the pressure-response curve, and the anchor teeth can be expected to move as much as the teeth that are desired to move (anchorage is lost). With extremely high force (A3-M3), the anchor teeth might move more than the teeth it was desired to move. Although the third possibility is theoretical and may not be encountered clinically, both the first and second situations are seen in clinical orthodontics. This principle explains the efficacy of light forces in controlling anchorage, and why heavy force destroys anchorage. In this example, treatment is not complete because the roots of the lingually tipped incisors will have to be uprighted at a later stage, but twostage treatment with tipping followed by uprighting can be used as a means of controlling anchorage. This would mean that the reaction force distributed over the posterior teeth would be reduced by half, and as a consequence, these teeth would move half as much. It is important to note again, however, that successful implementation of this strategy requires light force. If the force were large enough to bring the posterior teeth into their optimum movement range, it would no longer matter whether the anterior segment tipped or was moved bodily. Using too much force would disastrously undermine this method of anchorage control. This result could happen, of course, if such high force were used that the smaller segment was placed beyond the greatest tooth movement range, while the larger segment was still in it (see Figure 8-22). Because the effect would be highly traumatic, it would be an undesirable way to deliberately manage anchorage. In fact, it is not certain that the amount of tooth movement in response to applied force really decreases with very high force levels in any circumstance, and so this type of differential movement may not really exist.

Oogonia enlarge to form primary oocytes before birth; for this reason acne during pregnancy boy or girl betnovate 20 gm fast delivery, no oogonia are shown in Figures 2-1 and 2-3 acne 2 week purchase betnovate with paypal. As a primary oocyte forms acne jensen buy betnovate 20 gm mastercard, connective tissue cells surround it and form a single layer of flattened acne tools discount betnovate online amex, follicular epithelial cells (see. The primary oocyte enclosed by this layer of cells constitutes a primordial follicle (see. As the primary oocyte enlarges during puberty, the follicular epithelial cells become cuboidal in shape and then columnar, forming a primary follicle (see. The primary oocyte soon becomes surrounded by a covering of amorphous acellular glycoprotein material, the zona pellucida. Scanning electron microscopy of the surface of the zona pellucida reveals a regular meshlike appearance with intricate fenestrations. Primary oocytes begin the first meiotic division before birth, but completion of prophase does not occur until adolescence. The follicular cells surrounding the primary oocyte are believed to secrete a substance, oocyte maturation inhibitor, which keeps the meiotic process of the oocyte arrested. Postnatal Maturation of Oocytes Beginning during puberty, usually one follicle matures each month and ovulation occurs, except when oral contraceptives are used. The long duration of the first meiotic division (up to 45 years) may account in part for the relatively high frequency of meiotic errors, such as nondisjunction (failure of paired chromatids to dissociate), that occur with increasing maternal age. The primary oocytes in suspended prophase (dictyotene) are vulnerable to environmental agents such as radiation. No primary oocytes form after birth in females, in contrast to the continuous production of primary spermatocytes in males. As a follicle matures, the primary oocyte increases in size and, shortly before ovulation, completes the first meiotic division to give rise to a secondary oocyte and the first polar body. Unlike the corresponding stage of spermatogenesis, however, the division of cytoplasm is unequal. At ovulation, the nucleus of the secondary oocyte begins the second meiotic division, but progresses only to metaphase, when division is arrested. If a sperm penetrates the secondary oocyte, the second meiotic division is completed, and most cytoplasm is again retained by one cell, the fertilized oocyte (see. The other cell, the second polar body, also a small nonfunctional cell, soon degenerates. There are approximately two million primary oocytes in the ovaries of a newborn female, but most regress during childhood so that by adolescence no more than 40, 000 remain. Of these, only approximately 400 become secondary oocytes and are expelled at ovulation during the reproductive period. The number of oocytes that ovulate is greatly reduced in women who take oral contraceptives because the hormones in them prevent ovulation from occurring. The oocyte is surrounded by the zona pellucida and a layer of follicular cells, the corona radiata (see. The oocyte also has an abundance of cytoplasm containing yolk granules, which may provide nutrition to the dividing zygote during the first week of development. With respect to sex chromosome constitution, there are two kinds of normal sperm: 23, X and 23, Y, whereas there is only one kind of normal secondary oocyte: 23, X (see. In the foregoing descriptions and illustrations, the number 23 is followed by a comma and an X or Y to indicate the sex chromosome constitution. The difference in the sex chromosome complement of sperms forms the basis of primary sex determination. The likelihood of chromosomal abnormalities in the embryo increases after the mother is 35. In older mothers, there is an appreciable risk of Down syndrome or some other form of trisomy in the infant (see Chapter 20). The older the parents are at the time of conception, the more likely they are to have accumulated mutations that the embryo might inherit. For fathers of children with fresh mutations, such as the one causing achondroplasia, this age relationship has continually been demonstrated. This does not hold for all dominant mutations and is not an important consideration in older mothers.

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High-pull headgear to the upper molars skin care 6 months before wedding buy betnovate online from canada, in conjunction with a standard removable retainer to maintain tooth position skin care network barnet ltd purchase generic betnovate online, also can be effective acne 37 weeks pregnant buy generic betnovate 20gm, but the intraoral appliance is better tolerated and controls eruption of lower as well as upper posterior teeth skin care in 30s purchase betnovate paypal. Excessive vertical growth and eruption of the posterior teeth often continue until late in the teens or early twenties, so retention also must continue well beyond the typical completion of active treatment. A patient with a severe open bite problem is particularly likely to benefit from having conventional maxillary and mandibular retainers for daytime wear and an open bite bionator as a nighttime retainer from the beginning of the retention period. Retention of Lower Incisor Alignment Not only can continued skeletal growth affect occlusal relationships, it also has the potential to alter the position of teeth. If the mandible grows forward or rotates downward, the effect is to carry the lower incisors into the lip, which creates a force tipping them distally. Incisor crowding also accompanies the downward and backward rotation of the mandible seen in skeletal open bite problems (see Figure 17-6). A retainer in the lower incisor region is needed to prevent crowding from developing until growth has declined to adult levels. It often has been suggested that orthodontic retention should be continued, at least on a part-time basis, until the third molars have either erupted into normal occlusion or been removed. The implication of this guideline, that pressure from the developing third molars causes late incisor crowding, is almost surely incorrect (see Chapter 5). On the other hand, because eruption of third molars or their extraction usually does not take place until the late teen years, the guideline is not a bad one in its emphasis on prolonged retention in patients who are continuing to grow. Most adults, including those who had orthodontic treatment and once had perfectly aligned teeth, end up with some crowding of lower incisors. In a group of patients who had first premolar extraction and treatment with the edgewise appliance, only about 30%had perfect alignment 10 years after retainers were removed and nearly 20%had marked crowding. It seems likely that late mandibular growth is the major contributor to this crowding tendency. It makes sense therefore to routinely retain lower incisor alignment until mandibular growth has declined to adult levels. Timing of Retention: Summary In summary, retention is needed for all patients who had fixed orthodontic appliances to correct intra-arch irregularities. It should be: Essentially full time for the first 3 to 4 months, except that removable retainers not only can but should be removed while eating, and fixed retainers should be flexible enough to allow displacement of individual teeth during mastication (unless periodontal bone loss or other special circumstances require permanent splinting). For practical purposes, this means that nearly all patients treated in the early permanent dentition will require retention of incisor alignment at least until their late teens, and in those with skeletal disproportions initially, part-time use of a functional appliance or extraoral force probably will be needed. Removable Appliances as Retainers Removable appliances can serve effectively for retention against intra-arch instability and are also useful as retainers in patients with growth problems (in the form of modified functional appliances or part-time headgear). If permanent retention is needed, a fixed retainer should be used in most instances, and fixed retainers (see the following section of this chapter) are also indicated for intraarch retention when irregularity in a specific area is likely to be a problem. Hawley Retainers By far, the most common removable retainer is the Hawley retainer, designed in the 1920s as an active removable appliance. A, A Hawley retainer for a patient with maxillary premolar extractions, with the anterior bow soldered to Adams clasps on the first molars so that the extraction site is held closed. B, the adjustment loop of the Hawley anterior bow often keeps the wire from having full contact with the canines. If good control of the canines is needed, as in this patient whose canines were facially positioned before treatment, a wire that extends across the canines can be soldered to an anterior bow that crosses distal to the lateral incisor. C, In a patient whose second molars have erupted, a wraparound outer bow soldered to C-clasps on the second molars provides a way to avoid interference as the retainer wire crosses the occlusion, but a bow with such a long span will be quite flexible. D, For a mandibular retainer, the wire Hawley bow is less effective than a wire-reinforced acrylic bar that tightly contacts the lower incisors. This Moore design has almost completely replaced the Hawley design for lower removable retainers that extend to the posterior teeth. E, A removable maxillary retainer with a clear outer bow, which fits more tightly than a metal wire and is better esthetically but cannot be adjusted to modify tooth positions without starting over with a new retainer. Because it covers the palate, it automatically provides a potential bite plane to control overbite. The ability of this retainer to provide some tooth movement was a particular asset with fully banded fixed appliances, since one function of the retainer was to close band spaces between the incisors.

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Bonding Materials A successful bonding material must meet a set of formidable criteria: it must be dimensionally stable; it must be quite fluid acne remedies discount betnovate 20gm mastercard, so that it penetrates the enamel surface; it must have excellent inherent strength; and it must be easy to use clinically skin care malaysia purchase 20 gm betnovate otc. The new cements do not have as much bond strength with metal brackets as a widely used etch-and-rinse bonding material acne 5 weeks pregnant safe betnovate 20gm, but one of them already has the same strength with ceramic brackets skin care equipment suppliers purchase line betnovate. Their possible advantage is less decalcification around the brackets because of fluoride release (see further discussion below); their great disadvantage is significantly less strength and therefore a greater chance of loose brackets that require rebonding during treatment. Direct Bonding During direct bonding, bracket position is determined intraorally by the clinician during the bonding procedure. Even when most attachments are bonded indirectly (as described below), direct bonding is much more efficient whenever a single bracket must be repositioned. After preparation of the tooth surface, either a chemically activated composite resin with a very rapid setting time or a light-activated material can be used. The major difficulty with direct bonding is that the dentist must be able to judge the proper position for the attachment and must carry it to place rapidly and accurately. There is less opportunity for precise measurements of bracket position or detailed adjustments than there would be at the laboratory bench. It is generally conceded that for this reason, direct bonding does not provide as accurate a placement of brackets as indirect bonding. On the other hand, direct bonding is easier, faster (especially if only a few teeth are to be bonded), and less expensive (because the laboratory fabrication steps are eliminated). Steps in the direct bonding technique when using a light-activated resin for each bracket are illustrated in Figure 10-26. Light-cured resins now are used more frequently than chemically activated resins because the newer light-cured materials have more flexibility in working time and usually have higher bond strengths. Indirect Bonding Indirect bonding is done by accurately placing the brackets on dental casts in a laboratory, then using a template or tray to transfer the bracket positions to the patient. The advantage is more precise location of brackets than is possible with direct bonding because the teeth can be examined from all angles without the limitations of cheeks and saliva. Indirect setups can be done by the clinician in the office laboratory, but more frequently they now are done on stereolithographic casts made from impressions sent to a company (Cadent, E-Models, others) that also produces digital casts as part of diagnostic records. An alginate impression, poured relatively rapidly in the office lab, gives an accurate enough working cast for indirect bonding, but more stable impressions are needed for later digital scanning. Laboratory and clinical steps in indirect bonding are illustrated in Figure 10-27. Obtaining optimal bond strength while minimizing flash around the bracket can be a challenge during indirect bonding, since the presence of a tray prevents removing uncured flash. The composite resin is placed on the tooth surface in unpolymerized form, while the polymerization catalyst is placed on the back of the brackets. When the tray carrying the brackets is placed against the tooth surface, the resin immediately beneath the bracket is activated and polymerizes, but excess resin around the margins of the brackets does not polymerize and can easily be scaled away when the bracket tray is removed. Some studies, however, have found increased bond failures with this technique because it relies on diffusion for proper polymerization. An alternative is to use a chemical cure resin that is mixed prior to application to the brackets and teeth, but care must be taken to minimize excess resin. Finally, a flowable light-cured material can be used with a transparent tray, but polymerizing the resin at each bracket through or around the tray takes more time than using a chemical cure. With any of these techniques, proper isolation is critical for obtaining adequate bond strength. Custom brackets that were manufactured for an individual patient require precise placement that can be achieved only by indirect bonding. More generally, the poorer the visibility, the more difficult direct bonding becomes and the greater the indication for an indirect approach. Bonding an isolated lingual hook or button is not difficult, but precisely positioning the attachments for a lingual appliance is, and even the placement of a fixed lingual retainer is done more easily with indirect technique and a transfer tray. Debanding/Debonding It is as important to remove a fixed appliance safely as to place it properly. Bands are largely retained by the elasticity of the band material as it fits around the tooth. This is augmented by the cement that seals between the band and the tooth, but a band retained only by cement was not fitted tightly enough. No orthodontic band cement bonds strongly to enamel (which is why band cements cannot be used to bond brackets).

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